I’ve written before about Daniel Amen and his network of Amen Clinics, that (amongst other things) give utterly unnecessary doses of radiation to children. To briefly recap, Amen is a psychiatrist, author, motivational speaker etc. who has built his reputation and fortune on performing brain scans and then wildly exaggerating their diagnostic and prognostic usefulness. His clinics use an imaging modality called SPECT, a largely obsolete technology with terrible spatial resolution that’s been superseded by PET and MRI for most clinical and research purposes. The only real advantage of SPECT is that it’s much, much cheaper to perform than either PET or MRI, which is, of course, precisely why he uses it. He’s been at this a while too. This article in Wired from 2008 contains some choice quotes:
“Let’s look at your scans.” He takes the images that he printed out this morning and puts them side by side on a large table. He points to several views of the surface of my brain. “What I see here is that activity in your prefrontal cortex is low at rest but becomes better when you concentrate, and your thalamus becomes more active, too. I think this means you have a predisposition to depression.”
I nod. Scrutinizing the scans some more, he says, “You need to be busy to be happy. Your brain is cool at rest. You need stuff in your life to feel alive, together, and connected.” He looks at another view, this one showing only the most active regions of my brain. “In this scan, you have increased activity in your thalamus, your two basal ganglia, and your cingulate cortex.” He picks up a pen and draws a line connecting these four regions to the right lateral temporal lobe. “I call this the diamond plus.’ It’s a pattern of angst, and we see it in people who have had significant trauma in their lives.”
And these are the scans that he’s supposedly looking at while making these judgements:
What?! You can’t diagnose conditions like depression in an individual subject from even the very best brain scans, and you certainly can’t see the effects of such nebulous existential concepts like ‘angst’. What the hell is ‘angst’ supposed to mean in this context anyway?! He might as well be saying “The connections between your Shatner’s Bassoon and the peri-sinovial labio-ventral cortex is unusually cromulent and this might predispose you to brilligness, and excessive slithy toveing.” So, yeah, he’s a colossal bullshitter, who must have to keep a fire extinguisher handy at all times to dampen down the constant spontaneous combustion happening in his pants. This is nowhere more true than in the adverts for his clinics. Here’s one from the clinics LinkedIn page:
Brains get significantly less lumpy-looking after treatment – good to know. But hang on – brains are lumpy-looking. They’re covered in ridges and bumps! These smooth-looking pretty-coloured brains that Amen seems to think are great actually resemble lissencephaly; a very serious condition where the developing brain lacks the normal cortical folds. In this case, I’m pretty sure that the smoothness of the images is produced by the fact that the SPECT imaging methods he uses are so poor that they simply can’t show that much detail of the cortical surface. Also, I’ve no idea what the pretty colour-washes are meant to signify, if anything. To show you how easy it is to create images like this, here are some I threw together in about five minutes using FSLView and a standard-space MRI template (the MNI152 1mm template, bundled with FSL), by varying the threshold of the 3D rendered surface:
I’ve written before about why presenting brain images out of context in this way can be extremely misleading. Here’s another choice Amen-sponsored example:
As if it really needed saying; utterly meaningless nonsense. A Google image search brings up loads more examples, but I won’t sully your eyeballs with them unnecessarily. Amen’s use of SPECT images in this way is a gargantuan 20-year effort in energetic turd-polishing of a staggeringly disingenuous and despicable type, and I’m frankly amazed that he still seems to have an active licence to practice medicine.
Many thanks to @CousinAmygdala (and others) who first showed me these kinds of ads, and who also coined the most excellent term ‘neurofearmongering’.
Commercial fMRI neurobollocks – no, you cannot record your dreams (yet).
Cash cow? I wish! But no.
With thanks to Micah Allen (@neuroconscience) for pointing this one out.
My day job is as an fMRI (functional magnetic resonance imaging) researcher, so you can imagine how tickled I was when I came across a brand-new neurobollocks-peddler who’s chosen to set up shop right on my patch!
Donald H. Marks is a New Jersey doctor who in 2013 set up a company called ‘Millennium Magnetic Technologies’. Readers old enough to remember Geocities sites from the mid-90s will probably derive some pleasant nostalgia from visiting the MMT website, which is refreshingly unencumbered by anything so prosaic as CSS. Anyway, MMT offer a range of services, under the umbrella of “disruptive patented specialty neuro imaging and testing services”. These include the “objective” documentation of pain, forensic interrogation using fMRI, and (most intriguingly) thought and dream recording.
This last one is something that’s expanded on at some length in a breathlessly uncritical article in the hallowed pages of International Business Times (no, me neither). According to the article:
“The recording and storing of thoughts, dreams and memories for future playback – either on a screen or through reliving them in the mind itself – is now being offered as a service by a US-based neurotechnology startup.
Millenium Magnetic Technologies (MMT) is the first company to commercialise the recording of resting state magnetic resonance imaging (MRI) scans, offering clients real-time stream of consciousness and dream recording.”
And he does this using his patented (of course) ‘cognitive engram technology’, and all for the low, low price of $2000 per session.
It’s clear from the article and the MMT website that he’s using some kind of MVPA (multi-voxel pattern analysis) technique with the fMRI data. This technique first came up about 10 years ago, and is based on machine learning algorithms. Briefly, an algorithm is trained, and ‘learns’ to distinguish differences in a set of fMRI data. The algorithm is then tested with a new set of data to see if what it learned can generalise. If the two sets of data contain the same features (e.g.the participant was exposed to the same stimulus in both scans) the algorithm will identify bits of the brain that contain a consistent response. The logic is that if a brain area consistently shows the same pattern of response to a stimulus, that area must be involved in representing some aspect of that stimulus. This family of techniques has turned out to be very useful in lots of ways, but one of the most interesting applications has been in so-called ‘brain-reading’ studies. In a sense, the decoding of the test data makes predictions about the mental state of the participant; it tries to predict what stimulus they were experiencing at the time of the scan. A relatively accessible introduction to these kinds of studies can be found here.
So, the good Dr Marks (who, by the way, has but a single paper using fMRI to his name on Pubmed) is using this technology to read people’s minds. However, needless to say, there are several issues with this. Firstly, to generate even a vaguely accurate solution, these algorithms generally need a great deal of data. The dream decoding study that MMT link to on their website (commentary, original paper) required participants to sleep in the MRI scanner in three-hour blocks, on between seven and ten occasions. Even after all that, the accuracy of the predictive decoding (distinguishing between two pairs of different stimuli, e.g. people vs. buildings) was only between 55 and 60%. Statistically significant, but not terribly impressive, given that the chance level was 50%.
My point here is not to denigrate this particular study (which is honestly, a pretty amazing achievement), it’s to make the point that this technology is not even close to being a practical commercial proposition. These methods are improving all the time, but they’re still a long way from being reliable, convenient, or robust enough to be a true sci-fi style general-purpose mind-reading technology.
This apparently doesn’t bother Dr Marks though. He’s charging people $2000 a session to have their thoughts ‘recorded’ in the vague hope that some kind of future technology will be able to play them back:
“The visual reconstruction is kind of crude right now but the data is definitely there and it will get better. It’s just a matter of refinement,” Marks says. “That information is stored – once you’ve recorded that information it’s there forever. In the future we’ll be able to reconstruct the data we have now much better.”
No. N. O. No. The data is absolutely, categorically not there. Standard fMRI scans these days record using a resolution of 2-3mm. A cubic volume of brain tissue 2-3mm on each side probably contains several hundred thousand neurons, each of which may be responding to different stimuli, or involved in different processes. fMRI is therefore a very, very blunt tool, in terms of capturing the fine detail of what’s going on. It’s like trying to take apart a swiss watch mechanism when the only tool you have is a giant pillow, and you’re wearing boxing gloves. A further complication is that we still have so much to learn about exactly how and where memories are actually represented and stored in the brain. To accurately capture memories, thoughts, and even dreams, we’ll have to use a much, much better brain-recording technology. It’s potentially possible someday (and that ‘someday’ might even be relatively close), but the technology simply hasn’t been invented yet.
So, the idea that you can read someone’s mind in a single session, and preserve their treasured memories on a computer hard disk for future playback is simply hogwash right now. I’m as excited by the possibilities in this area as the next geek, but it’s just not possible right now. Dr Marks is charging people $2000 a pop for a pretty useless service, no matter how optimistic he might be about some mythical kind of future mind-reading playback device.
NB. I’ve got a lot more to say about MMT’s other services too, but this post’s got a bit out of hand already, so I’ll save that for a future one…
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Posted in Commentary, Medical, Neuroimaging, Products
Tagged brain-reading, dreams, fmri, mind-reading, mvpa